Open AccessIndices of protein metabolism in rat blood upon study of chronic toxicity of melanin-based composition
Author(s) -
K. Dvorshchenko,
A. S. Dranitsina,
Ye. Torgalo,
Oleksandr Korotkyi,
Тетяна Володимирівна Берегова
Publication year - 2016
Publication title -
vìsnik. problemi regulâcìï fìzìologìčnih funkcìj/vìsnik kiïvsʹkogo nacìonalʹnogo unìversitetu ìmenì tarasa ševčenka. serìâ: problemi regulâcìï fìzìologìčnih funkcìj
Language(s) - English
Resource type - Journals
eISSN - 2616-6410
pISSN - 1728-2624
DOI - 10.17721/2616_6410.2016.21.79-81
Subject(s) - toxicity , melanin , albumin , metabolism , alanine aminotransferase , endocrinology , medicine , chronic toxicity , urea , protein metabolism , therapeutic index , alanine , drug metabolism , pharmacology , drug , chemistry , biology , biochemistry , amino acid
The chronic toxicity of the drug based on melanin was investigated on the basis of indices of protein metabolism in blood serum of rats of both sexes. It is found that by action of melanin in the therapeutic dose of 0.3 mg × kg-1 during 90 days the concentration of total protein, albumin, urea, alanine aminotransferase and aspartate aminotransferase remained within the control values in the serum of male and female rats. It was shown that by action of melanin in ten-fold therapeutic dose of 3 mg × kg-1 for 90 days serum alanine aminotransferase was 1.36 times higher of the control value in females; at the same time all other analyzed parameters remained at the control level in both males and females.