Open AccessProtein kinase C participation in the mechanisms of vascular tone disturbance upon diabetes mellitus. Part 4
Author(s) -
Igor V. Kizub,
O. Kharchenko,
Oleksandra Kostiuk,
L. Ostapchenko,
Kateryna I. Klymenko,
Anatoly I. Soloviev
Publication year - 2016
Publication title -
vìsnik. problemi regulâcìï fìzìologìčnih funkcìj/vìsnik kiïvsʹkogo nacìonalʹnogo unìversitetu ìmenì tarasa ševčenka. serìâ: problemi regulâcìï fìzìologìčnih funkcìj
Language(s) - English
Resource type - Journals
eISSN - 2616-6410
pISSN - 1728-2624
DOI - 10.17721/2616_6410.2016.21.61-66
Subject(s) - protein kinase c , vascular smooth muscle , gene silencing , diabetes mellitus , rna interference , microbiology and biotechnology , protein kinase a , small interfering rna , vascular tone , kinase , medicine , chemistry , vasodilation , pharmacology , biology , endocrinology , smooth muscle , gene , biochemistry , rna
Diabetes mellitus (DM) is acompaining by vascular tone desorders development. Regulatory enzyme protein kinase C (PKC) is involved in mechanisms of these desorders development. Numerous studies have demonstrated that contractile responces of vascular smooth muscle are enchansed in DM and endothelium-independent PKC-mediated mechanisms are involved in this process. Such mechanisms are PKC-mediated inhibition of Ca2+ activated K+ channels (BKCa) in vascular smooth muscle cells (SMCs) and SMCs myophilaments Ca2+ sensitization. PKC is a potential therapeutic target for treating vascular diabetic complications. A few compounds among PKC inhibitors already exist, such as ruboxistaurin, indolylmaleimide and its derivatives. Recently discovered method of RNA-interference (RNAi) is an essential gene-silencing tool and can also be used for PKC inhibition and DMassociated vascular complicaions elimination.