Open AccessFunctioning of the antioxidant system of rat tissues poisoned with heavy metals
Author(s) -
I. V. Kalinin,
B A Tsudzevich
Publication year - 2016
Publication title -
vìsnik. problemi regulâcìï fìzìologìčnih funkcìj/vìsnik kiïvsʹkogo nacìonalʹnogo unìversitetu ìmenì tarasa ševčenka. serìâ: problemi regulâcìï fìzìologìčnih funkcìj
Language(s) - English
Resource type - Journals
eISSN - 2616-6410
pISSN - 1728-2624
DOI - 10.17721/2616_6410.2016.21.5-8
Subject(s) - glutathione peroxidase , chemistry , glutathione , antioxidant , tbars , lipid peroxidation , superoxide dismutase , catalase , cadmium , glutathione reductase , biochemistry , enzyme , organic chemistry
To investigate the functioning of antioxidant system in blood and liver of rats, poisoned of heavy metals (copper sulfate, zinc sulfate, cadmium sulfate and lead nitrate) on lipid peroxidation and on activity of glutathione-dependent enzymes of blood and liver of poisoned rats are shown in this article. It is shown that the introduction of heavy metals in rats leads to an increase in blood and liver TBARS-products and diene conjugates. Under the action of heavy metals decreases the activity of catalase and superoxide dismutase. A reduction in the activity of glutathione peroxidase and glutathione transferase under the influence of high doses of heavy metals. Under the action of heavy metals reduced glutathione content in rat tissues.