Functioning of the antioxidant system of rat tissues poisoned with heavy metals | Zendy

I. V. Kalinin | Zendy; B A Tsudzevich | Zendy

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Functioning of the antioxidant system of rat tissues poisoned with heavy metals

Author(s) -

I. V. Kalinin,

B A Tsudzevich

Publication year - 2016

Publication title -

bulletin of taras shevchenko national university of kyiv series problems of physiological functions regulation

Language(s) - English

Resource type - Journals

eISSN - 2616-6410

pISSN - 1728-2624

DOI - 10.17721/2616_6410.2016.21.5-8

Subject(s) - glutathione peroxidase , chemistry , glutathione , antioxidant , tbars , lipid peroxidation , superoxide dismutase , catalase , cadmium , glutathione reductase , biochemistry , enzyme , organic chemistry

To investigate the functioning of antioxidant system in blood and liver of rats, poisoned of heavy metals (copper sulfate, zinc sulfate, cadmium sulfate and lead nitrate) on lipid peroxidation and on activity of glutathione-dependent enzymes of blood and liver of poisoned rats are shown in this article. It is shown that the introduction of heavy metals in rats leads to an increase in blood and liver TBARS-products and diene conjugates. Under the action of heavy metals decreases the activity of catalase and superoxide dismutase. A reduction in the activity of glutathione peroxidase and glutathione transferase under the influence of high doses of heavy metals. Under the action of heavy metals reduced glutathione content in rat tissues.

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