Features of the bradykinin-induced contraction of the gastric smooth muscle depending on the concentration of compounds based on 3-substituted-1,4-benzodiazepin-2-ones | Zendy

Pavlo Virych | Zendy; O. V. Shelyuk | Zendy; V. S. Martynyuk | Zendy; V. І. Pavlovsky | Zendy

Open Access

Features of the bradykinin-induced contraction of the gastric smooth muscle depending on the concentration of compounds based on 3-substituted-1,4-benzodiazepin-2-ones

Author(s) -

Pavlo Virych,

O. V. Shelyuk,

V. S. Martynyuk,

V. І. Pavlovsky

Publication year - 2016

Publication title -

bulletin of taras shevchenko national university of kyiv series problems of physiological functions regulation

Language(s) - English

Resource type - Journals

eISSN - 2616-6410

pISSN - 1728-2624

DOI - 10.17721/2616_6410.2016.21.19-23

Subject(s) - bradykinin , contraction (grammar) , chemistry , smooth muscle , muscle contraction , endocrinology , medicine , biophysics , biochemistry , biology , receptor

The effect of compounds based on 3-substituted-1,4-benzodiazepine-2-ones on contractile activity of smooth muscles of the rat's stomach was analyzed. Action substances MX-1626, MX-1775 for the smooth muscle contraction of like competitive inhibitor of bradykinin – des-Arg9- [Leu8]-Bradykinin acetate, which is observed as increase normalized rate of contraction with increasing of bradykinin concentration and characterized by a slowdown in the first phase of contraction. The most effective 3-subtituted 1,4-benzodiazepin-2-ones was at low concentrations of bradykinin, increasing it concentration their effect is reduced.

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