Open AccessProangiogenic effect of newly synthesized compounds-analogue of inhibitors HIF-1
Author(s) -
T.V. Nikolaienko,
L. Garmanchuk,
S.I. Orysyk,
V.I. Pekhnyo
Publication year - 2016
Publication title -
bulletin of taras shevchenko national university of kyiv series problems of physiological functions regulation
Language(s) - English
Resource type - Journals
eISSN - 2616-6410
pISSN - 1728-2624
DOI - 10.17721/2616_6410.2016.20.85-89
Subject(s) - nitric oxide , chemistry , stereochemistry , pharmacology , biochemistry , biology , organic chemistry
The effect of new compounds analog of inhibitors of HIF-1 on the metabolic and proliferative status of endothelial cells have been studied. It was shown that syn-isomer possesses of proproliferative effect and antiapoptotic effect with anti-isomer. These effects are consistent with the rates of glucose uptake and production of nitric oxide.
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