Open AccessThe effect of analgesia with omnopon and dexketoprofen on the endocytic activity of phagocytes of different localization on the surgical tumor resection model
Author(s) -
N. Khranovska,
O. Skachkova,
R. I. Sydor,
Larysa Skivka
Publication year - 2016
Publication title -
vìsnik. problemi regulâcìï fìzìologìčnih funkcìj/vìsnik kiïvsʹkogo nacìonalʹnogo unìversitetu ìmenì tarasa ševčenka. serìâ: problemi regulâcìï fìzìologìčnih funkcìj
Language(s) - English
Resource type - Journals
eISSN - 2616-6410
pISSN - 1728-2624
DOI - 10.17721/2616_6410.2016.20.69-73
Subject(s) - spleen , medicine , opioid , endocytic cycle , anesthesia , pharmacology , pathology , immunology , receptor , endocytosis
We aimed to compare the effect of anesthesia with opioid analgesics omnopon and non-selective COX-2 inhibitor dexketoprofen on the endocytic activity of phagocytes of different localization sites on the model of surgical tumor removal. The study used 50 C57/black mice, which were transplanted with Lewis lung carcinoma in the hind paw pad. After 22 days the tumor paw was amputated. Analgesics (omnopon 10 mg/kg, dexketoprofen – 20 mg/kg) was administered 30 minutes before the operation and once per day for 3 days after surgery. Assessment of endocytic activity of phagocytes was performed by flow cytometry before the surgery, at days 1 and 3 after the surgery. It was found that dexketoprofen analgesia maintain the endocytic activity of blood and spleen phagocytes in the postoperative period. At day 3 postsurgery in dexketoprofen-treated animals phagocytic activities of blood and spleen granulocytes were higher compared to the group receiving opioid analgesia by 70% and 86% respectively. Phagocytic indices of blood and spleen monocytes were also 2 times higher at dexketoprofen-treated mice. Thus, dexketoprofen analgesia maintains the activity of blood and spleen phagocytes in mice after the surgical tumor removal at a much higher level as compared with the omnopon analgesia.