Open AccessPhospholipid composition of the inner mitochondrial membrane of rat hepatocytes upon development of different types of steatohepatosis
Author(s) -
D. Voieikova,
L.І. Stepanova,
Tetyana Beregova,
L. Ostapchenko,
Maryana Kondro
Publication year - 2016
Publication title -
vìsnik. problemi regulâcìï fìzìologìčnih funkcìj/vìsnik kiïvsʹkogo nacìonalʹnogo unìversitetu ìmenì tarasa ševčenka. serìâ: problemi regulâcìï fìzìologìčnih funkcìj
Language(s) - English
Resource type - Journals
eISSN - 2616-6410
pISSN - 1728-2624
DOI - 10.17721/2616_6410.2016.20.30-33
Subject(s) - cardiolipin , inner mitochondrial membrane , phospholipid , mitochondrion , biochemistry , oxidative stress , inner membrane , composition (language) , membrane , biology , oxidative phosphorylation , chemistry , microbiology and biotechnology , linguistics , philosophy
Nonalcoholic fatty liver disease (NAFLD) or steatohepatosis has recently become widespread, but its pathogenesis has not been thoroughly understood for today. Most scientists have appropriated a central role in the mechanisms of its development to mitochondria and so-called "mitochondrial dysfunction," which is observed in most animal models and in most patients. The aim of this work was to determine phospholipid composition of inner mitochondrial membrane of rat hepatocytes under diet-induced and glutamate-induced steatohepatosis, as well as to compare the data about developing steatohepatosis of different types.Obtained data indicate the disruption of normal functional state of the inner mitochondrial membrane under the conditions of diet-induced and glutamate-induced steatohepatosis. Amount of oxidized forms of the major phospholipids including cardiolipin, indicates the increasing oxidative stress under the conditions of both steatohepatosis types.