Open AccessThe antimicrobial activity and toxicity od alkyltetrahydroisoquinolones
Author(s) -
E. O. Terent’eva,
С. А. Сасмаков,
Sh. A. Azimov,
В. И. Виноградова,
D. M. Abdurakhmanov,
Z. S. Khashimova,
A. Sh. Saidov
Publication year - 2017
Publication title -
vìsnik - kiïvsʹkij nacìonalʹnij unìversitet ìmenì tarasa ševčenka. bìologìâ
Language(s) - English
Resource type - Journals
ISSN - 1728-2748
DOI - 10.17721/1728_2748.2017.74.51-55
Subject(s) - candida albicans , antimicrobial , antifungal , microbiology and biotechnology , corpus albicans , antibacterial activity , toxicity , chemistry , minimum inhibitory concentration , bacteria , gram , biology , organic chemistry , genetics
The antibacterial and antifungal activity against gram-positive and gram-negative bacteria and Candida albicans fungal strain for alkyltetrahydroisoquinoline derivatives were evaluated. It was established, that 1,11-bis(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)undecan shows pronounced antibacterial properties against all the microorganism strains and strong antifungal activity against Candida albicans with greater inhibition area than the reference drug. IC50 value of the compound is 2,1±0,1 μg/ml, LD50 value is 324,9±18,2 mg/kg.