ACTION OF CHONDROITIN SULFATE ON THE GLUTATHIONE SYSTEM IN BLOOD SERUM AT СARRAGEENAN-INDUCED ACUTE INFLAMMATION | Zendy

K. Dvorshchenko | Zendy; M. Ashpin | Zendy; E. Torgalo | Zendy; M. Tymoshenko | Zendy; Л. І. Остапченко | Zendy

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ACTION OF CHONDROITIN SULFATE ON THE GLUTATHIONE SYSTEM IN BLOOD SERUM AT СARRAGEENAN-INDUCED ACUTE INFLAMMATION

Author(s) -

K. Dvorshchenko,

M. Ashpin,

E. Torgalo,

M. Tymoshenko,

Л. І. Остапченко

Publication year - 2017

Publication title -

bulletin of taras shevchenko national university of kyiv series biology

Language(s) - English

Resource type - Journals

ISSN - 1728-2748

DOI - 10.17721/1728_2748.2017.73.60-62

Subject(s) - glutathione , glutathione reductase , chondroitin sulfate , glutathione peroxidase , chemistry , carrageenan , inflammation , pharmacology , biochemistry , endocrinology , enzyme , medicine , glycosaminoglycan

Increase of content of oxidized glutathione (GSSG) is fixed in blood serum at carrageenan-induced rat paw inflammation, as well as increase of the glutathione transferase activity. Upon the same experimental conditions, the level of reduced glutathione (GSH) and activity of glutathione peroxidase and glutathione reductase were decreased. All above mentioned indices was closer to control values in animals treated simultaneously with сarrageenan and drug on the basis of chondroitin sulfate.

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