Open AccessACTION OF CHONDROITIN SULFATE ON THE GLUTATHIONE SYSTEM IN BLOOD SERUM AT СARRAGEENAN-INDUCED ACUTE INFLAMMATION
Author(s) -
K. Dvorshchenko,
M. Ashpin,
E. Torgalo,
M. Tymoshenko,
L. Ostapchenko
Publication year - 2017
Publication title -
vìsnik - kiïvsʹkij nacìonalʹnij unìversitet ìmenì tarasa ševčenka. bìologìâ
Language(s) - English
Resource type - Journals
ISSN - 1728-2748
DOI - 10.17721/1728_2748.2017.73.60-62
Subject(s) - glutathione , glutathione reductase , chondroitin sulfate , glutathione peroxidase , chemistry , carrageenan , inflammation , pharmacology , biochemistry , endocrinology , enzyme , medicine , glycosaminoglycan
Increase of content of oxidized glutathione (GSSG) is fixed in blood serum at carrageenan-induced rat paw inflammation, as well as increase of the glutathione transferase activity. Upon the same experimental conditions, the level of reduced glutathione (GSH) and activity of glutathione peroxidase and glutathione reductase were decreased. All above mentioned indices was closer to control values in animals treated simultaneously with сarrageenan and drug on the basis of chondroitin sulfate.