Open AccessANTIVIRAL AND IMMUNOSTIMULATORY POTENTIAL OF FLUORINE CONTAINING TRIAZOLES
Author(s) -
Krystyumenko,
Anna Golovan,
Г. В. Баранова,
S. Zagorognya,
Yu. Shermolovytch
Publication year - 2016
Publication title -
vìsnik - kiïvsʹkij nacìonalʹnij unìversitet ìmenì tarasa ševčenka. bìologìâ
Language(s) - English
Resource type - Journals
ISSN - 1728-2748
DOI - 10.17721/1728_2748.2016.72.24-27
Subject(s) - in vivo , nucleoside , drug , triazole , chemistry , antiviral drug , pharmacology , biology , stereochemistry , organic chemistry , microbiology and biotechnology
The problem of finding effective antiviral drugs caused high morbidity and wide spread of viral infections. The purpose of this study was to investigate of antyherpetic activity fluorinated nucleoside G8 and G9 compounds (2-N-substituted-4-tosyl-5polyfluoroalkyl-1,2,3-triazole) in vivo models and determine their immunomodulatory potential. Shown significant inhibition of virus reproduction under the influence of the compounds at concentrations of 0.4 and 0.5 mg/kg, which was more effective of acyclovir. Protection ratio amounted to 80%. Increasing level of IFN-γ and IL-2 in serum of animals, indicated available immunomodulatory effect fluorinated nucleoside compounds. Our studies indicated that there is antiherpetic, immunomodulatory activity of fluorine containing triazole and there is need to in-depth study of the mechanisms of this process.