Open AccessAcute and sub-acute toxicity studies of an extract from white bean pods under the condition of its intragastric administration
Author(s) -
M. Kuznietsova,
Tetiana Halenova,
О. Savchuk
Publication year - 2016
Publication title -
vìsnik - kiïvsʹkij nacìonalʹnij unìversitet ìmenì tarasa ševčenka. bìologìâ
Language(s) - English
Resource type - Journals
ISSN - 1728-2748
DOI - 10.17721/1728_2748.2016.71.31-35
Subject(s) - acute toxicity , toxicity , medicine , pharmacology , adverse effect , traditional medicine , toxicology , biology
The article is devoted to the studies of acute and sub-acute toxicity of dry extract from white bean (P. vulgaris) pods. The acute toxicity study of the extract was carried out according to the conventional classification of K.K Sidorov and showed that the extract refers to low-toxic substances (LD 50 following its intragastric administration is greater than 2000 mg/kg). The study of extract sub-acute toxicity showed the increasing of relative liver and kidney weight, which may indicate the existence of adverse effects of the extract under the conditions of its long-term administration.