Open AccessFeatures of calcium signaling in ischemic injury nervous tissue – of neurons in the hippocampus
Author(s) -
Anastasiia Maistrenko,
Nana Voitenko
Publication year - 2015
Publication title -
vìsnik - kiïvsʹkij nacìonalʹnij unìversitet ìmenì tarasa ševčenka. bìologìâ
Language(s) - English
Resource type - Journals
ISSN - 1728-2748
DOI - 10.17721/1728_2748.2015.70.70-73
Subject(s) - excitotoxicity , neuroprotection , hippocampal formation , neuroscience , glutamate receptor , ischemia , hippocampus , calcium , homeostasis , regeneration (biology) , calcium in biology , medicine , biology , microbiology and biotechnology , receptor
This review describes the features of the systems to ensure the restoration of calcium homeostasis of hippocampal neurons during ischemic injury. High levels of intracellular Ca 2+, glutamate excitotoxicity activity and the formation of free radicals during ischemia are a major damaging factors, leading to further damage to hippocampal neurons. Understanding the mechanisms able to prevent the development of damage today is key for the development of post- and preconditioning neuroprotective strategies.