Features of calcium signaling in ischemic injury nervous tissue – of neurons in the hippocampus | Zendy

Anastasiia Maistrenko | Zendy; Nana Voitenko | Zendy

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Features of calcium signaling in ischemic injury nervous tissue – of neurons in the hippocampus

Author(s) -

Anastasiia Maistrenko,

Nana Voitenko

Publication year - 2015

Publication title -

bulletin of taras shevchenko national university of kyiv series biology

Language(s) - English

Resource type - Journals

ISSN - 1728-2748

DOI - 10.17721/1728_2748.2015.70.70-73

Subject(s) - excitotoxicity , neuroprotection , hippocampal formation , neuroscience , glutamate receptor , ischemia , hippocampus , calcium , homeostasis , regeneration (biology) , calcium in biology , medicine , biology , microbiology and biotechnology , receptor

This review describes the features of the systems to ensure the restoration of calcium homeostasis of hippocampal neurons during ischemic injury. High levels of intracellular Ca 2+, glutamate excitotoxicity activity and the formation of free radicals during ischemia are a major damaging factors, leading to further damage to hippocampal neurons. Understanding the mechanisms able to prevent the development of damage today is key for the development of post- and preconditioning neuroprotective strategies.

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