Open AccessFullerene C60 impact on changes of contraction speed of ischemicaly damaged rat soleus muscle
Author(s) -
Dmytro Nozdrenko
Publication year - 2014
Publication title -
vìsnik - kiïvsʹkij nacìonalʹnij unìversitet ìmenì tarasa ševčenka. bìologìâ
Language(s) - English
Resource type - Journals
ISSN - 1728-2748
DOI - 10.17721/1728_2748.2014.68.11-14
Subject(s) - soleus muscle , contraction (grammar) , pharmacology , medicine , intramuscular injection , drug , therapeutic effect , chemistry , anesthesia , cardiology , skeletal muscle
The effect of water-soluble C 60 fullerene (C 60 FAS) at a dose of 1 mg/kg on ischemic damagd muscles (muscle soleus) of rat was studied. The therapeutic effect of C 60 FAS was analyzed under intravenous and intramuscular injection. An evident C 60 FAS protective effect on the dynamics of ischemic damage muscles contraction was revealed. In particular, it was found that in most cases the protective effect of С 60 FAS with intramuscular administration at 15-17% is more effective than intravenous administration of this drug. This clearly indicates that C 60 FAS can be considered as a promising therapeutic agent for the prevention and correction of contractile activity of ischemic damage muscles.