Open AccessEffect of the polymorphism BDNF rs6265 G/A in Mexican outpatient children with autism spectrum disorders
Author(s) -
Mirna Edith Morales-Marín,
Miriam Aguilar,
Lilia Albores,
A. Martinez Ballesteros,
Xóchitl Castro,
Carlos Chicalote,
Amalia Gómez,
Nora Gutiérrez,
Nuria Lanzagorta,
F. Navarro López,
Carla Márquez,
Nimsi Morales,
Omar Náfate,
Patricia Sánchez,
Ana María Balboa,
Humberto Nicolini
Publication year - 2018
Publication title -
salud mental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.163
H-Index - 24
ISSN - 0185-3325
DOI - 10.17711/sm.0185-3325.2018.019
Subject(s) - rs6265 , single nucleotide polymorphism , autism , snp , population , oncology , psychology , medicine , polymorphism (computer science) , genetic association , genotype , clinical psychology , genetics , psychiatry , biology , gene , environmental health
. The study of autistic spectrum disorders (ASD) at the genetic level is extremely important to understand their origin. In Mexico, there are few works addressed from this perspective. Objective. We investigated the role of the Brain Derived Neurotrophic Factor ( BDNF ) gene variant rs6265 G/A for single nucleotide polymorphism analysis in Mexican children with ASD using a case-control association design. Method. We made a pilot study by case-control analysis adjusting by gender, age, and ancestry. Results. Our study found no association between the BDNF rs6265 gene polymorphism and ASD [ p = .419, OR = 1.597 (.514, 4.967)]. Discussion and conclusion. Worldwide, the results of case-control association studies with the rs6265 of BDNF are controversial and do not always replicate. This may be due to the ethnicity of our population and additional factors not studied in the present work. Our study suggests that the SNP rs6265 is not contributing for ASD susceptibility in Mexican population.