Open AccessEpidemiology of kidney disease in patients with COVID-19
Author(s) -
Н. Г. Кульченко
Publication year - 2020
Publication title -
issledovaniâ i praktika v medicine
Language(s) - English
Resource type - Journals
eISSN - 2410-1893
pISSN - 2409-2231
DOI - 10.17709/2409-2231-2020-7-3-7
Subject(s) - context (archaeology) , pandemic , disease , medicine , kidney , tropism , immunology , virology , covid-19 , intensive care medicine , biology , virus , infectious disease (medical specialty) , paleontology
At the turn of 2019–2020, humanity was struck by a new viral infection SARS-CoV-2 (COVID-19), which quickly spread in many countries and reached the scale of a pandemic. A feature of the SARS-CoV-2 virus (COVID-19) is it’s high contagiousness, virulence and tropism to many cells of human organs. Human infection primarily occurs through the respiratory tract. Then, getting into the respiratory divisions, SARS-CoV-2 (COVID-19) can enter the blood and interact with cells of other organs. It is already known that COVID-19 uses the angiotensin converting enzyme type 2 (ACE2) receptor to enter the cell, and ACE2 is highly expressed in the kidneys. Therefore, kidney disease is a risk factor for COVID-19 infection, exacerbating the clinical course of the disease. This article discusses the main aspects of the etiology and pathogenesis of kidney diseases in the context of the COVID-19 pandemic. Since there is currently no specific vaccine against the SARS-CoV-2 virus, and there is no effective drug for the treatment of COVID-19, the identification of risk factors and early medical correction of kidney diseases can help reduce the overall incidence and mortality. Conclusion . Early detection and correction of violations of filtration and excretory function of the kidneys, including adequate hemodynamic support and restriction of nephrotoxic drugs, can improve the prognosis of recovery of a patient with COVID-19.