Open AccessNovel approaches to treatment of locally advanced rectal cancer
Author(s) -
А. А. Качмазов,
Л. В. Болотина,
А. Л. Корниецкая,
Ю. Б. Карагодина,
И. В. Дрошнева,
А. А. Феденко
Publication year - 2020
Publication title -
tazovaâ hirurgiâ i onkologiâ
Language(s) - English
Resource type - Journals
eISSN - 2686-7435
pISSN - 2686-9594
DOI - 10.17650/2686-9594-2020-10-3-4-73-83
Subject(s) - medicine , colorectal cancer , mesorectum , chemoradiotherapy , oncology , clinical trial , quality of life (healthcare) , adjuvant , adjuvant chemotherapy , chemotherapy , cancer , total mesorectal excision , nursing , breast cancer
Combination of neoadjuvant chemoradiotherapy with subsequent total mesorectum excision and 6-months of adjuvant chemotherapy remains a standard approach to treatment of locally advanced rectal cancer (T3 or T4 and / or N1–3; M0) for more than 15 years, which is reflected in practical guidelines of most leading oncological societies. However, recent data suggests possibilities of more individualized treatment conceptions with a potential of further improvement of long-term therapy outcomes and patient’s quality of life. In this paper we present review of results of clinical trials which investigated new approaches to treatment of locally advanced rectal cancer.