Open AccessSmall GTPase Rab3B: biological properties and possible role in carcinogenesis
Author(s) -
Anton A. Budko,
P. A. Khesina,
L. M. Diakov,
Н. Л. Лазаревич
Publication year - 2019
Publication title -
uspehi molekulârnoj onkologii
Language(s) - English
Resource type - Journals
eISSN - 2413-3787
pISSN - 2313-805X
DOI - 10.17650/2313-805x-2018-5-4-78-85
Subject(s) - gtpase , rab , subfamily , carcinogenesis , ras superfamily , small gtpase , biology , guanosine , cancer research , microbiology and biotechnology , ran , gene , genetics , biochemistry , signal transduction , enzyme , gtp'
Proteins of the superfamily of small guanosine triphosphate hydrolase (GTPase) perform various functions: from the control of cell proliferation to the regulation of vesicular transport. The superfamily of small GTPase Ras includes more than 150 proteins, devided to 5 major families (Arf, Ran, Rho, Ras and Rab), and plays an important role in carcinogenesis. Compared to the other families, the Rab family was investigated by relatively small number studies, which does not equally reflect their role in malignant transformation processes. In our review we have focused on both the subfamily Rab3 and its poorly investigated member Rab3B. Recent findings allow to consider Rab3B not only as a promising diagnostic or prognostic marker for several types of neoplasms, but also is a potential target for antitumor therapy. Our analysis of publicly available transcriptional databases revealed that kidney, lung and liver cancer patients with low Rab3B gene expression demonstrate a better overall five-year survival.