Open AccessA STUDY OF THE ROLE OF MICRORNA IN PITUITARY ADENOMA
Author(s) -
Ilgiz Gareev,
Ozal Beylerli
Publication year - 2018
Publication title -
uspehi molekulârnoj onkologii
Language(s) - English
Resource type - Journals
eISSN - 2413-3787
pISSN - 2313-805X
DOI - 10.17650/2313-805x-2018-5-2-8-15
Subject(s) - microrna , biology , carcinogenesis , gene , gene expression , regulation of gene expression , pituitary adenoma , endogeny , bioinformatics , adenoma , genetics , endocrinology
MicroRNAs are a new class of small non-coding RNAs, a length of 18–22 nucleotides that play a decisive role as posttranscriptional regulators of gene expression. Due to the large number of genes, regulated microRNAs, microRNAs are involved in many cellular processes. The study of the impairment of the expression of the target genes of microRNA, often associated with changes in important biological characteristics, provides a significant understanding of the role of microRNAs in oncogenesis. New evidence suggests that aberrant microRNA expression or dysregulation of endogenous microRNAs affects the onset and development of tumors, including adenomas of the pituitary gland. In this review, the significance of some microRNAs in the pathology of the pituitary adenoma will be assessed, as well as data on the study of microRNAs as therapeutic targets and new biomarkers.