Open AccessInfluence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck
Author(s) -
Л. В. Болотина,
Т. И. Дешкина,
А. Л. Корниецкая,
С А Кравцов,
Т. В. Устинова,
А. А. Пайчадзе,
А. Д. Каприн,
А. А. Феденко
Publication year - 2020
Publication title -
opuholi golovy i šei
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.14
H-Index - 1
eISSN - 2411-4634
pISSN - 2222-1468
DOI - 10.17650/2222-1468-2020-10-2-10-21
Subject(s) - cetuximab , pembrolizumab , medicine , oncology , head and neck squamous cell carcinoma , chemotherapy , head and neck cancer , head and neck , clinical practice , basal cell , quality of life (healthcare) , radiation therapy , cancer , surgery , immunotherapy , physical therapy , colorectal cancer , nursing
The results of the clinical studies have a direct impact on clinical practice. The main criteria for the effectiveness of treatment method are increasing the overall life expectancy and improving its quality. In the treatment of common forms of squamous cell carcinoma of the head and neck, induction chemotherapy can be used, including platinum drugs, preferably in combination with cetuximab. Next immuno-oncological drugs should be prescribed. In the future, in the 1st line of therapy, it is possible to replace cetuximab with pembrolizumab or monotherapy with pembrolizumab, which allows to increase the effectiveness of treatment and reduce its toxicity. The article presents 3 clinical observations that demonstrate the possibility of integration the results of clinical research in practice.