Open AccessThe clinical case of infertility treatment caused by male factor (globozoospermia type 1) by the intracytoplasmic morphologically normal sperm injection with activation of the oocytes by Ca2+-ionophore
Author(s) -
В В Литвинов,
А. Н. Сулима,
Margarita A. Kharitonova,
А. А. Клепуков,
И. Ю. Ермилова,
Ю. Ю. Маклыгина
Publication year - 2019
Publication title -
andrologiâ i genitalʹnaâ hirurgiâ
Language(s) - English
Resource type - Journals
eISSN - 2412-8902
pISSN - 2070-9781
DOI - 10.17650/2070-9781-2019-20-3-78-85
Subject(s) - intracytoplasmic sperm injection , infertility , male infertility , oocyte activation , andrology , ionophore , spermatogenesis , sperm , medicine , gynecology , biology , pregnancy , embryo , microbiology and biotechnology , oocyte , genetics , calcium
A case of infertility treatment in couple with a male factor, the severe form of teratozoospermia (total globozoospermia (type 1)) was presented. This pathology is extremely rare (0.1 % at andrological patients). Globozoospermia (type 1) is an insufficiently studied disease and is a severe disorder of spermatogenesis that leads to 100 % of male infertility. Assisted reproductive technologies with using of intracytoplasmic morphologically normal sperm injection and the activation of oocytes – by Ca2+-ionophore A23187 in a man with globozoospermia (type 1) helped in the treatment of infertility in matrimony. Pregnancy and childbirth proceeded favorably.