Open AccessEnvironmental exposure to endocrine disruptors on semen quality of men
Author(s) -
С. В. Чигринец,
G. V. Bryuhin
Publication year - 2018
Publication title -
andrologiâ i genitalʹnaâ hirurgiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.138
H-Index - 1
eISSN - 2412-8902
pISSN - 2070-9781
DOI - 10.17650/2070-9781-2018-19-3-42-47
Subject(s) - triclosan , semen , semen quality , endocrine system , nonylphenol , dna fragmentation , bisphenol a , chemistry , bisphenol , testosterone (patch) , andrology , medicine , endocrinology , hormone , biology , environmental chemistry , apoptosis , biochemistry , organic chemistry , pathology , programmed cell death , epoxy
The study objective is to investigate the correlations between endocrine disruptors (bisphenol A, triclosan and 4-nonylphenol) exposure, measured on semen and semen quality of men, total testosterone in the plasma. Materials and methods. We measured semen bisphenol A, triclosan and 4-nonylphenol concentrations of 41 men by gas chromatography/ mass spectrometry. According to the World Health Organization guidelines, we divided our patients into 2 groups: normozoospermia and patozoospermia. And furthermore, total plasma testosterone and index DNA fragmentation spermatozoa were determined. The results were statistically processed using the Mann–Whitney U-test and correlation analysis. A p-value less than 0.05 was considered significant. Results. Bisphenol A was detected in 100 % of semen samples, triclosan – in 85,4 %, 4-nonylphenol – in 97,6 %, with a median concentration of 0.108, 0.17 and 0.165 ng/ml respectively. The groups were different statistically significant for levels of bisphenol A, triclosan and index DNA fragmentation spermatozoa (р <0.001, р = 0.033, р = 0.005 respectively). We found significant negative correlations between concentration of triclosan and percentage of normal morphology (p = 0.004), percentage of progressively motile spermatozoa (p = 0.049) and the positive correlation – between concentration of triclosan and percentage of DNA fragmentation spermatozoa (p <0,001). Аlso we found significant negative correlations between concentration of bisphenol A and total count (p = 0.04), percentage of progressively motile spermatozoa (p <0.001), percentage of normal morphology (p = 0.002), levels of total testosterone in plasma (p = 0.047). We demonstrated the synergy of investigated endocrine disruptors on semen quality. Conclusion. Semen bisphenol A and triclosan concentrations have a negative correlation with the parameters of the ejaculate. Environmental levels of bisphenol A negatively correlated with testosterone levels in plasma.