Open AccessThe microbiome role in pathogenesis of inflammatory and immune alterations of gastrointestinal tract in pediatric patients with cancer
Author(s) -
Daria Morgacheva,
Ю. В. Диникина,
Ю. К. Тошина,
М. Б. Белогурова
Publication year - 2021
Publication title -
onkogematologiâ
Language(s) - English
Resource type - Journals
eISSN - 2413-4023
pISSN - 1818-8346
DOI - 10.17650/1818-8346-2021-16-2-86-93
Subject(s) - mucositis , dysbiosis , gastrointestinal tract , microbiome , immunology , medicine , cancer , immune system , pathogenesis , disease , inflammatory bowel disease , gastrointestinal cancer , antimicrobial , radiation therapy , colorectal cancer , bioinformatics , biology , gut flora , microbiology and biotechnology
Infectious complications remain one of the most significant problem associated with anticancer therapy in oncological patients. Cytotoxic, radiation and antibacterial therapy induce dysbiosis and gastrointestinal mucosal barrier injury. These changes lead to the mucositis, thereby increasing the risk of endogenous microflora translocation with following probable development of severe infectious and inflammatory diseases. In addition, current evidence suggests that there is a relationship between gut microbiome disturbances and post-transplant graft versus host disease development. The article presents the existing paradigms of determining the role of gastrointestinal tract functional condition in cancer patients in order to optimize prevention and antimicrobial treatment approaches.