Open AccessMicrosatellite instability (MSI, EMAST) in the pathogenesis of follicular lymphoma
Author(s) -
К. А. Сычевская,
С К Кравченко,
Н В Рисинская,
А Е Мисюрина,
Eleikulina,
Fatima Babaeva,
Andrey Sudarikov
Publication year - 2021
Publication title -
onkogematologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.118
H-Index - 3
eISSN - 2413-4023
pISSN - 1818-8346
DOI - 10.17650/1818-8346-2021-16-2-56-69
Subject(s) - microsatellite instability , follicular lymphoma , loss of heterozygosity , dna mismatch repair , microsatellite , lymphoma , cancer research , pathology , biology , pathogenesis , medicine , cancer , genetics , colorectal cancer , allele , gene
Background. Genetic instability, an important phenomenon involved in oncogenic transformation and tumor progression, is associated with the insufficiency of the multicomponent DNA repair complex, in particular, the nucleotide mismatch repair (MMR) system. The MMR defect manifests itself as abnormalities in DNA microsatellite repeats, or microsatellite instability (MSI). In the studies of colorectal cancer, the role of MSI in prognostication of the disease, and defining the choice of specific therapy with immune checkpoint inhibitors has been proven. However, in lymphatic system tumors, the significance of this phenomenon is poorly understood. Determination of genetic instability in the onset of follicular lymphoma, a disease characterized by a heterogeneous course, may have prognostic value. Objective: to determine the genetic instability at the onset of follicular lymphoma. Materials and methods. Here we report an analysis of 24 microsatellite repeats and amelogenin loci in tumor cells of 46 follicular lymphoma patients. Results. In the studied cohort, lesions in microsatellite repeats were presented by MSI in 9 cases (19.6 %) and the loss of heterozygosity (LOH) in 19 cases (41.3 %). Most frequent lesions were found for the SE33 marker located at the q14 locus of chromosome 6. A significant association was shown between MSI and the double-hit follicular lymphoma group with rearrangements of the MY C and BCL 2 /BCL 6 genes. Conclusion. Thus, our data indicate that the MSI phenomenon might be involved in the pathogenesis of the lymphatic tumors and particularly follicular lymphoma. However further studies on the expanded cohorts of patients are required to define the possible prognostic value of MSI in lymphatic tumors.