Open AccessExperience with the use of bendamustine (Rozustin®): safety and efficacy
Author(s) -
А. А. Семенова,
А. В. Аракелян,
P. A. Zeynalovа,
Г. С. Тумян,
В. Б. Ларионова,
Т. Т. Валиев,
Ф. М. Аббасбейли,
О. Л. Тимофеева,
Alina Antipova,
О. А. Лопухова
Publication year - 2020
Publication title -
onkogematologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.118
H-Index - 3
eISSN - 2413-4023
pISSN - 1818-8346
DOI - 10.17650/1818-8346-2020-15-3-27-37
Subject(s) - bendamustine , medicine , oncology , drug , salvage therapy , chemotherapy , hodgkin lymphoma , lymphoma , intensive care medicine , pharmacology , rituximab
Background. Bendamustine is one of the main drugs included in the arsenal of cytostatic agents that are used in oncohematology. In Russia, the drug was registered at the end of 2010 under the commercial name Ribomustin (company Astellas). At the end of 2018, two national generics of bendamustine appeared on the Russian market – Rozustin® (Rafarma) and Kovada (Biocad). Materials and methods. In 2019 the department of hemoblastosis chemotherapy of the N. N. Blokhin National Medical Research Center of Oncology received the drug bendamustin (Rozustin®) (Rafarma, Russia). This article presents the first experience of using Rozustin® in patients with various lymphoproliferative diseases. Most often, the drug was used for relapsed or refractory classical Hodgkin’s lymphoma. Results and conclusion. The high effectiveness, acceptable toxicity profile compared to alternative “salvage” regimens, ease of implementation, and the possibility of a full collection of hematopoietic stem cells followed by high-dose chemotherapy and autologous stem cell transplant, confirm the good potential of the combined program with the inclusion of the drug bendamustine (Rozustin®).