Open AccessRECONSTITUTION OF B-CELLS IMMUNITY AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
Author(s) -
С. В. Чулкова,
Н. Н. Субботина,
Galina Petrova,
Н. В. Сидорова,
О. П. Колбацкая,
Н. Н. Тупицын,
А. Ю. Нуртазина
Publication year - 2020
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2019-19-2-22-30
Subject(s) - lymphopoiesis , stem cell , transplantation , immunology , immunity , hematopoietic stem cell transplantation , haematopoiesis , biology , population , immune system , medicine , microbiology and biotechnology , environmental health
The restoration of B-cell immunity is a key component of the success of allogeneic hematopoietic stem cell transplantation. In most cases,the restoration of B-lymphopoiesis is a slow and often incomplete process, which is accompanied by a decrease in the tolerance of the recipientto bacterial, viral, fungal pathogens. This process is influenced by a number of factors that determine its effectiveness and pace. It isimportant to restore not only the size of the B-cell population, but also their functional usefulness. The article provides an analysis of modern literature data on the significance of the restoration of B-cell immunity after allogeneic hematopoietic stem cell transplantation,a review of the main factors affecting the process of B-lymphopoiesis, and their prognostic component.