Open AccessOncolitical viruses in the therapy of malignant neoplastic diseases
Author(s) -
Н. К. Клаан,
Л. П. Акиньшина,
Т. А. Пронина
Publication year - 2019
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2018-17-4-6-19
Subject(s) - oncolytic virus , virotherapy , genome , virology , viral therapy , virus , computational biology , cancer research , biology , medicine , covid-19 , gene , pathology , genetics , disease , infectious disease (medical specialty)
The main types of oncolytic viruses and the mechanisms of their action on the tumor cells are described in this review. Examples of optimization of the viral genome are given with a view to enhancing the oncolytic properties of the virus. The achievements in the field of development of antitumour agents based on oncolytic viruses and methods of their application in oncology are described.