Open AccessIndolocarbazole derivatives – a promising class of anticancer drugs
Author(s) -
М. П. Киселева,
В. С. Покровский,
В. В. Татарский,
Л. М. Борисова,
И. С. Голубева,
Л. В. Эктова
Publication year - 2019
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2018-17-4-20-26
Subject(s) - christian ministry , chemistry , intracellular , pharmacology , mechanism of action , computational biology , biology , biochemistry , political science , in vitro , law
The paper discusses the possible mechanisms of antitumor action of indolocarbazole derivatives. Here we present a data that show interaction drugs based on indolocarbazole derivatives with several intracellular targets and consequently activation different pathways of cell death. Also we present results of our studies on the mechanisms of antitumor action of compounds LCS-1006 and LCS-1208 synthesized in the N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia.