Open AccessEGFR Tyrosine kinase inhibitors in the treatment of metastases of non-small cell lung cancer in the brain
Author(s) -
Д. Р. Насхлеташвили,
Vera Gorbunova,
М. Б. Бычков,
А. Kh. Bekyashev,
В. Б. Карахан,
В. А. Алешин,
Е. А. Москвина
Publication year - 2018
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2018-17-2-22-30
Subject(s) - medicine , radiosurgery , central nervous system , lung cancer , brain metastasis , radiation therapy , adverse effect , tyrosine kinase inhibitor , targeted therapy , metastasis , oncology , tyrosine kinase , lung , cancer , cancer research , pathology , receptor
Brain metastases are very common in non-small cell lung cancer. The condition of these patients is complicated and difficult to treat, and adverse reactions following treatment can affect the nervous system, which severely reduces quality of life. In this review we discuss the methods in use from local therapies such as whole brain irradiation, stereotactic radiosurgery and central nervous system surgery to systemic therapy. We also highlight drugs for targeted therapy of non-small lung cancer cells metastasis in the brain that have been effective in the treatment of metastases in central nervous system.