Open AccessPOTENTIAL ANTITUMOR ACTIVITY STUDIES ON SOME COORDINATION COMPOUNDS OF RARE EARTH ELEMENTS WITH ANTIPYRINE
Author(s) -
И. С. Голубева,
Н. П. Яворская,
М. А. Барышникова,
Д. А. Афанасьева,
А. А. Рудакова,
Г. Н. Апрышко,
Н. С. Рукк,
А. Ю. Скрябина
Publication year - 2016
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2016-15-4-89-95
Subject(s) - histogenesis , rare earth , in vivo , in vitro , chemistry , ligand (biochemistry) , solid tumor , ascites , cancer , pharmacology , cancer research , combinatorial chemistry , stereochemistry , biochemistry , biology , medicine , receptor , genetics , mineralogy , immunohistochemistry
The aim of this study was to examine the anticancer activity of rare earth elements complexes with antipirin. Materials and methods. We have studied the cytotixic activity of in vitro and antineoplastic activity in vivo of 28 iodides and perchlorates containing as a ligand antipirine. Results. Here we show, that non of tested compounds exert cytotoxic action on 5 human cancer cell lines of different histogenesis at a concentration of 100 ßM. However, we observe that two complexes of antipirine derivatives with iodides of gadolinium and neodymium possess anti-tumor activity in experiments with transplantable solid tumors. Conclusion. The data obtained indicate the feasibility of further studies of these two complexes on a larger number of mice, with changing doses and routes of administration. We also suggest the investigation of these compounds on ascites tumors.