Open AccessIMMUNOLOGICAL PHENOTYPE OF PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH PRIMARY OPERABLE BREAST CANCER
Author(s) -
Т. Н. Заботина,
О. В. Короткова,
Sh. G. Hakimova,
А А Борунова,
D Tabakov,
И. К. Воротников,
З. Г. Кадагидзе
Publication year - 2016
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2016-15-4-37-39
Subject(s) - cd19 , breast cancer , cd3 , cd16 , cd8 , medicine , flow cytometry , peripheral blood , monoclonal antibody , antigen , immunology , cancer , antibody
Objecive. The investigation is devoted to study subpopulation structure of lymphocytes from peripheral blood of patients, suffering from breast cancer. Materials and methods. Peripheral blood of 70 patients with breast cancer and 39 healthy women was analyzed using the flow cytometry method with monoclonal antibodies to CD3, CD4, CD8, CD16, CD56, CD19, CD45 antigens. Results. Statistically significant disturbance of linear structure of lymphocytes (T-cells CD45+/CD3+/CD19-; B-cells CD45+/CD3-/ CD19+; NK-cells CD45+CD3-CD16+56+) detected only in the analysis of individual immunograms, but not in analysis of whole group of breast cancer patients. Conclusion. Based on analysis of frequence of occurrence of disturbances of cancer breast patients with low values of ratio CD4/CD8, it was detected 4 different variants of disturbance.