Open AccessNONCLINICAL STUDY OF THE TOXICITY OF A NEW ANTICANCER DRUG ОRMUSTIN ON SMALL LABORATORY ANIMALS
Author(s) -
V. A. Chaley,
O. I. Konyaevа,
Н. П. Ермакова,
А. А. Николина,
В. М. Бухман,
N. Yu. Kulbachevskaya
Publication year - 2015
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2015-14-4-65-72
Subject(s) - toxicity , drug , pharmacology , medicine , nitrosourea , drug administration , acute toxicity , anticancer drug , maximum tolerated dose , toxicology , biology , chemotherapy
The paper presents the results of the study of «acute» toxicity and some results of the study of «subchronic» toxicity of Ormustin, a new anticancer drug belonging to nitrosourea class, in small laboratory animals. In the experiments the laboratory animals - hybrid mice (C57Bl/6J×DBA/2)F1 male and female and outbred male and female rats have been used. On the results of study has been obtained the calculated toxic doses of Ormustin at intravenous administration of the drug in mice and rats; has been given the preliminary assessment of the impact of Ormustin on organs and systems of rats at multiple intravenous administration.