Open AccessSTUDY OF ACUTE TOXICITY OF NOVEL ANTITUMOR PREPARATION BASED ON DERIVATIVE OF INDOLOCARBAZOLE - LCS-1208
Author(s) -
А. А. Николина,
N. Ju. Kul'bachevskaja,
O. I. Konjaeva,
V. A. Chalej,
Н. П. Ермакова,
В. М. Бухман
Publication year - 2015
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2015-14-4-59-64
Subject(s) - pharmacology , acute toxicity , derivative (finance) , toxicity , intraperitoneal injection , median lethal dose , drug , chemistry , medicine , financial economics , economics
The research has been devoted to the study of acute toxicity of preparation based on derivative of indolocarba- zole - LCS-1208 in mice of both sexes and in rats of both sexes at intravenous and intraperitoneal administration of the drug. In the experiments the laboratory animals - outbred white rats and hybrid mice (C57Bl/6JxDBA2)Fl (B6D2F1) have been used. On the results of study has been obtained the calculated toxic doses of novel preparation based on derivative of indolocarbazole at intraperitoneal administration of the drug in mice of both sexes.