Open AccessBASIC DETERMINANTS OF MELANOMA STEM CELL
Author(s) -
A. A. Vartanyan,
M. V. Oborotova
Publication year - 2015
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2015-14-2-7-16
Subject(s) - melanoma , stem cell , cancer stem cell , cancer research , metastasis , stroma , skin cancer , cancer , cell , medicine , biology , pathology , microbiology and biotechnology , immunohistochemistry , genetics
Melanoma is considered to be the deadliest form of skin cancer. For years it has been accepted that all melanoma cells in tumor are capable of tumor formation and each of them has the ability to initiate the metastasis. At present a stem cell theory of cancer has been developed, which purports that a subpopulation of self-renewing tumor cells is responsible for tumorogenesis, neoangiogenesis and stroma building. In this review we will discuss the basic determinants of melanoma stem cell and melanoma stem cell targeting implications.