Open AccessSUPPRESSION OF GLIOBLASTOMA CELLULAR TRANSPORTERS SENSITIZES TARGET CELLS TO INFECTION WITH ONCOLYTIC VIRUS IN THE PRESENCE OF IONIZING RADIATION
Author(s) -
Ilya Ulasov,
Natalya Kaverina,
З. Г. Кадагидзе,
A. Yu. Baryshnikov
Publication year - 2015
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2015-14-2-65-70
Subject(s) - oncolytic virus , glioma , cancer research , verapamil , cancer cell , ionizing radiation , oncolytic adenovirus , cancer , cell culture , glioblastoma , in vitro , biology , medicine , tumor cells , irradiation , physics , genetics , nuclear physics , calcium , biochemistry
It is already established that verapamil inhibits Pgp expression in the brain tumor cancer cells such as medulloblastoma. The aim of this study is to investigate the sensitivity of glioblastoma cancer cells to verapamil and its combination with oncolytic adenoviral victor CRAd-S-pK7. In vitro using U87 and U251 human glioblastoma cell lines, we obtained experimental data suggesting a therapeutic effect of verapamil and CRAd-S-pK7. Moreover, we established that verapamil improves anti-glioma effect of oncolytic adenoviral vector in the presence of ionizing radiation, which results into more suppression of U251 cancer cells via inhibition of their proliferation.