Open AccessIMMUNOGENIC CANCER-TESTIS ANTIGENS AND THEIR GENES IN MALIGNANT TUMORS
Author(s) -
P. V. Golyshko,
К А Барышников,
A. Yu. Baryshnikov
Publication year - 2015
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2015-14-2-31-38
Subject(s) - cancer , prostate cancer , ovarian cancer , medicine , melanoma , lung cancer , cancer research , pancreatic cancer , gene expression , gene , pathology , biology , biochemistry
The analysis of CTG and CTA expression in malignant tumors described in this review has been showed that different types of tumors are significantly different from each other according to the frequency of CTA mRNA expression. Melanoma, ovarian cancer and lung cancer have a very high frequency of CTA expression. Lymphoma, kidney cancer, pancreatic cancer have a low frequency of CTA expression. Breast cancer, bladder cancer, prostate cancer demonstrate an intermediate level of CTA expression. High degree malignant tumors in late clinical stage with metastases showed a greater incidence of CTA -gene expression. CTA-genes are expressed together in tumor. If the tumor is positive for one CTA-gene then the expression of several genes is possible. Immunogenic CTA-s are a well object for anti-tumor vaccines creating.