Open AccessPHOTODYNAMIC THERAPY OF RAT SARCOMA M-1 WITH PHOTOSENSITIZER AMIDOAMINCHLORINE
Author(s) -
М. А. Каплан,
А. И. Малыгина,
Г В Пономарева,
Alesya Mikhailovskaya,
В. В. Дрожжина,
Л. М. Архипова,
J. S. Osipchuk
Publication year - 2015
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2015-14-1-53-56
Subject(s) - photosensitizer , photodynamic therapy , medicine , radiation therapy , irradiation , cancer research , chemistry , photochemistry , organic chemistry , physics , nuclear physics
Efficacy of photodynamic therapy with intraperitoneal introduction photosensitizer Amidoaminchlorine on rat sarcoma M1 model was studied. The aim of this study was to determine minimum effective dose of photosensitizer and parameters of laser radiation for achievement of tumor full regress. Dynamics of photosensitizer accumulation in tumor and healthy tissues was studied to definite the time of photodynamic therapy. Antitumor efficacy different doses of photosensitizer and various parameters of laser radiation were investigated. As a result, optimal term of photodynamic therapy, photosensitizer minimum effective dose and parameters of laser irradiation were established.