Open AccessMOLECULAR MECHANISMS OF MULTIDRUG RESISTANCE OVERCOMING BY LIPOSOMAL ANTITUMOR DRUGS
Author(s) -
Барышникова Мария Анатольевна,
А. Ю. Барышников,
Д. А. Афанасьева
Publication year - 2015
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2015-14-1-3-10
Subject(s) - liposome , cisplatin , multiple drug resistance , pharmacology , doxorubicin , apoptosis , drug resistance , drug , p glycoprotein , mechanism of action , chemistry , medicine , in vitro , chemotherapy , biology , biochemistry , microbiology and biotechnology
The liposomal antitumor drugs cell death induction mechanism has been analyzed in this work. Liposomal dosage forms of doxorubicin, cisplatin and aranosa overcome drug resistance. However, the mechanism of overcoming drug resistance by this drugs is different. Liposomal doxorubicin overcomes multidrug resistance by liposomes binding with the P-glycoprotein in 185 position of glycine. Liposomal cisplatin overcomes monoresistance by external apoptosis gene activation. The liposomal aranosa does not use CD95/Fas signaling pathway of apoptosis. Thus, liposomal drug action mechanism depends on the type of cells, and on the antitumor drug, that is enclosed in a liposome and can be individualized in each case.