Open Access<i>BRCA</i> associated prostate cancer. <i>BRCA</i> heredity of one family
Author(s) -
А. А. Измайлов,
А. V. Sultanbaev,
К. V. Menshikov,
А. Ф. Насретдинов,
Ш. И. Мусин,
R. Т. Ayupov,
Н. И. Султанбаева,
Б. А. Ибрагимов,
A. R. Khasiev
Publication year - 2022
Publication title -
onkourologiâ
Language(s) - English
Resource type - Journals
eISSN - 1996-1812
pISSN - 1726-9776
DOI - 10.17650/1726-9776-2021-17-4-157-164
Subject(s) - medicine , prostate cancer , cancer , disease , oncology , population , prostate , heredity , genetic testing , genetics , biology , environmental health
In western European countries prostate cancer is one of the most common malignant disease among male population. Due to innovations in molecular genetics research technology over recent years genetic features of etiology and pathogenesis of prostate cancer have been discovered and this helped to distinguish people with high risk of prostate cancer development. Hereditary forms of malignant tumors occupy a special position due to association with mutations in BRCA1/2 gene in a group of patients with prostate cancer. The most important part of examination of patients with malignant diseases is medico-genetic counseling. It helps to reveal the hereditary of the disease. The detection of germinal mutations in BRCA1/2 gene helps to personify diagnostic measures for primary prophylaxis and treatment of prostate cancer. Here is a case of one patient with hereditary feature of prostate cancer with a mutation in BRCA1 gene. It is important to note that revealing mutations in BRSA gene helps to early diagnose malignant neoplasms. Screening measures to reveal germinal mutations in healthy population can improve early detection of such malignant diseases as breast cancer, prostate cancer and other malignant neoplasms.