Open AccessKIM-1 (kidney injury molecule 1) in the urine of renal cell carcinoma patients
Author(s) -
К. Ю. Канукоев,
Н. С. Сергеева,
Т. А. Кармакова,
Н. В. Маршутина,
М. П. Солохина,
К. М. Нюшко,
Б. Я. Алексеев,
А. Д. Каприн
Publication year - 2020
Publication title -
onkourologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 4
eISSN - 1996-1812
pISSN - 1726-9776
DOI - 10.17650/1726-9776-2020-16-3-21-28
Subject(s) - medicine , renal cell carcinoma , urology , urinary system , kidney cancer , stage (stratigraphy) , carcinoma , kidney , cancer , nephrectomy , gastroenterology , oncology , pathology , paleontology , biology
Objective : to assess the potential clinical significance of KIM-1 (kidney injury molecule 1) as a urinological marker for kidney cancer. Materials and methods . An enzyme-linked immunosorbent assay was used to assess urinary KIM-1 (uKIM-1 — kidney injury molecule 1) levels in 67 patients with renal cell carcinoma (RCC) and 36 healthy volunteers (a control group). Results . Both in patients and in healthy individuals, uKIM-1 levels were age independent. A difference between mean uKIM-1 values in RCC patients (2.4 ± 0.2 ng/ml) and the control group (0.7 ± 0.1 ng/ml) was statistically significant (p <0.0001). In RCC patients the higher uKIM-1 level was observed at more advanced clinical disease stages: the values increasedfrom 2.0 ± 0.2 ng/ml at the stage I and 3.0 ± 0.5 ng/ml at the stage II—III to 4.4 ± 1.2 ng/ml at the stage IV. In the group of patients with stage IRCC, most representative by the number of cases (n = 44) the uKIM-1 levels correlated with the tumor size and were increased in patients with different histological subtypes of the tumor, including clear cell, papillary and chromophobe RCC. After nephrectomy, a monotonous decrease in uKIM-1 level was observed, and after 6 days its values approached the mean value in the control group. Two days after kidney resection, uKIM-1 increased and then decreased, remaining elevated after 6 days. Conclusion . This study demonstrates that uKIM-1 can be attributed to potentially significant urine tumor-associated markers of RCC.