Open AccessPROGNOSTIC VALUE OF MATRIX METALLOPROTEINASE 9 IN RENAL CELL CARCINOMA
Author(s) -
Т. М. Черданцева,
И. П. Бобров,
С. В. Варламов,
М. Н. Мяделец,
I. V Klimachev,
А. М. Авдалян,
Д И Ганов,
А. Ф. Лазарев
Publication year - 2018
Publication title -
onkourologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 4
eISSN - 1996-1812
pISSN - 1726-9776
DOI - 10.17650/1726-9776-2018-14-3-17-24
Subject(s) - medicine , immunostaining , renal cell carcinoma , immunohistochemistry , pathology , matrix metalloproteinase , cancer cell , staining , cancer , metastasis
Objective: to assess matrix metalloproteinase 9 (MMP-9) expression in renal cell carcinoma cells and cells of intratumoral inflammatory infiltrates depending on clinical and morphological characteristics and postoperative survival. Materials and methods. We evaluated MMP-expression in 108 renal cancer tissue specimens. The intensity of immunohistochemical staining was estimated by measuring integral optical density in cytoplasm. Results. We found that the integral optical density of MMP-9 immunostaining in tumor cells and cells of intratumoral inflammatory infiltrates correlates with important prognostic factors for renal cancer, including histological type of cancer, TNM stage, tumor size, Fuhrman nuclear grade, metastasis, and 5-year postoperative survival. Conclusion. Integral optical density of MMP-9 immunostaining is an additional prognostic factor for renal cell carcinoma.