Open AccessDeep brain stimulation. How it controls movements in Parkinson’s disease?
Author(s) -
З. А. Залялова
Publication year - 2019
Publication title -
nejrohirurgiâ
Language(s) - English
Resource type - Journals
eISSN - 2587-7569
pISSN - 1683-3295
DOI - 10.17650/1683-3295-2019-21-3-93-99
Subject(s) - deep brain stimulation , neuroscience , dystonia , basal ganglia , psychology , neurogenesis , dyskinesia , tardive dyskinesia , epilepsy , depression (economics) , parkinson's disease , medicine , disease , psychiatry , central nervous system , schizophrenia (object oriented programming) , economics , macroeconomics
Deep brain stimulation (DBS) involves implantation of electrodes in the basal ganglia of the brain. Dysregulation of neuronal activity in these structures is the cause of motor disorders. DBS is used in many motor (Parkinson’s disease, essential tremor, dystonia, ticks, tardive dyskinesia and others), psychological, behavioral and affective (depression, obsessive-compulsive disorder, epilepsy and others) disorders, as well as in severe pain syndromes resistant to drug therapy. However, the mechanisms of action of DBS are not fully understood. Currently, different theories and hypotheses are considered which explain its mechanism of treatment: rate model, “jamming” theory, hypotheses about the effect on neurogenesis, astrocyte activity, increased brain circulation, electrotaxis, etc.