Open AccessAstrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation
Author(s) -
Andrew Xiao,
Hua Wang,
Pier Paolo Pandolfi,
David N. Louis,
Terry Van Dyke
Publication year - 2002
Publication title -
carolina digital repository (university of north carolina at chapel hill)
Language(s) - English
DOI - 10.17615/rx9d-ky66
Subject(s) - pten , cancer research , astrocyte , astrocytoma , mutation , glioma , chemistry , biology , pi3k/akt/mtor pathway , microbiology and biotechnology , signal transduction , neuroscience , genetics , central nervous system , gene