Open AccessCYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime]
Author(s) -
M. Z. Wang,
J. Y. Saulter,
E. Usuki,
Y.-L. Cheung,
M. Hall,
A. S. Bridges,
G. Loewen,
O. T. Parkinson,
C. E. Stephens,
J. L. Allen,
D. C. Zeldin,
D. W. Boykin,
R. R. Tidwell,
A. Parkinson,
M. F. Paine,
J. E. Hall
Publication year - 2006
Publication title -
carolina digital repository (university of north carolina at chapel hill)
Language(s) - English
DOI - 10.17615/hq31-xq37
Subject(s) - prodrug , enzyme , antiparasitic , microsome , demethylation , antiparasitic agent , chemistry , furan , biochemistry , human liver , stereochemistry , biology , organic chemistry , pharmacology , medicine , gene , gene expression , pathology , dna methylation