Open AccessLong-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.
Publication year - 1988
Publication title -
carolina digital repository (university of north carolina at chapel hill)
Language(s) - English
DOI - 10.17615/6c6f-rp98
Subject(s) - protein kinase c , phorbol ester , phosphoinositide 3 kinase , agonist , chemistry , signal transduction , stimulation , microbiology and biotechnology , protein kinase a , phosphorylation , endocrinology , medicine , biology , pi3k/akt/mtor pathway , receptor , biochemistry