Open AccessIn Vitro Hepatic Metabolism Explains Higher Clearance of Voriconazole in Children versus Adults: Role of CYP2C19 and Flavin-Containing Monooxygenase 3
Author(s) -
Souzan B. Yanni,
Pieter Annaert,
Patrick Augustijns,
Joseph G. Ibrahim,
Daniel K. Benjamin,
Dhiren R. Thakker
Publication year - 2010
Publication title -
carolina digital repository (university of north carolina at chapel hill)
Language(s) - English
DOI - 10.17615/4wq9-7j34
Subject(s) - flavin containing monooxygenase , cyp2c19 , monooxygenase , in vitro , voriconazole , pharmacology , drug metabolism , chemistry , metabolism , flavin group , biochemistry , medicine , cytochrome p450 , enzyme , dermatology , antifungal