Open AccessPeptidomimetic Escape Mechanisms Arise via Genetic Diversity in the Ligand-Binding Site of the Hepatitis C Virus NS3/4A Serine Protease
Author(s) -
Christoph Welsch,
Tetsuro Shimakami,
Christoph Hartmann,
Yan Yang,
Francisco S. Domingues,
Thomas Lengauer,
Stefan Zeuzem,
Stanley M. Lemon
Publication year - 2012
Publication title -
carolina digital repository (university of north carolina at chapel hill)
Language(s) - English
DOI - 10.17615/28t4-0431
Subject(s) - ns3 , serine protease , peptidomimetic , hepatitis c virus , virology , protease , ns2 3 protease , ligand (biochemistry) , binding site , chemistry , biology , virus , computational biology , genetics , biochemistry , enzyme , receptor , peptide