Open AccessAlkaloid Caulerpin and Cytotoxic Activity against NCL-H460 Lung Cancer Cells Isolated along with β-sitosterol from the Halimeda cylindracea Decaisne
Author(s) -
Iwan Dini,
Nunuk Hariani Soekamto,
Firdaus Firdaus,
Unang Supratman,
Jalifah Latip
Publication year - 2021
Publication title -
sains malaysiana
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.251
H-Index - 29
eISSN - 2735-0118
pISSN - 0126-6039
DOI - 10.17576/jsm-2021-5009-14
Subject(s) - alkaloid , cytotoxicity , chemistry , stereochemistry , ic50 , in vitro , mtt assay , cytotoxic t cell , two dimensional nuclear magnetic resonance spectroscopy , traditional medicine , lung cancer , hexane , chromatography , biochemistry , medicine
Alkaloid caulerpin (1), along with β-sitosterol (2), were isolated from the n-hexane extract of the macroalga Halimeda cylindracea Decaisne. The chemical structure was identified by a spectroscopic method including IR, MS, UV, NMR 1D, NMR 2D, and comparison with data of spectra previously reported. Compounds (1) and (2) were isolated for the first time from this macroalga. Compund (1) were evaluated for their cytotoxicity activity against NCL-H460 lung cancer cells in vitro and showed moderate activity with IC50 value of 20.05 µg/mL.