Open AccessProtective Effects of Acehnese Traditionally Fermented Coconut Oil (Pliek U Oil)1 and its Residue (Pliek U) in Ointment against UV Light Exposure: Studies on Male Wistar Rat Skin (Rattus novergicus)
Author(s) -
Nanda Earlia,
Mikyal Bulqiah,
Muslem Muslem,
Taufiq Karma,
Rivansyah Suhendra,
Arif Maulana,
Mohamad Amin,
Novi Reandy Sasmita,
Ghazi Mauer Idroes,
Crs Prakoeswa,
Eko Suhartono,
Khairan Khairan,
Rinaldi Idroes
Publication year - 2021
Publication title -
sains malaysiana
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.251
H-Index - 29
eISSN - 2735-0118
pISSN - 0126-6039
DOI - 10.17576/jsm-2021-5005-09
Subject(s) - active ingredient , ingredient , coconut oil , chemistry , erythema , melanin , residue (chemistry) , food science , traditional medicine , biology , pharmacology , biochemistry , dermatology , medicine
A protective effect of Acehnese traditionally fermented coconut oil (Pliek U oil) and its residue (Pliek U) have been studied against UVB radiation. The research was performed by preparing the active ingredient in ointment formulation and protective test in male Wistar rat skin (Rattus novergicus). Four different extraction methods were done to produce four active ingredients, that are Pliek U oil (PUO), ethanolic Pliek U oil extract (EPUOE), ethanolic Pliek U extract (EPUE), and ethanolic hexane residue Pliek U extract (EHRPUE). The protective effect was determined based on the erythema index (EI), melanin index (MI), and level of protein oxidation parameters. The protective level from each active ingredient was studied by PCA analysis. The result showed that the active ingredient could inhibit the redness and protein oxidation in skin tissue. PCA results show that concentration (20 v. 40%) does not affect the protection level of the active ingredients of Pliek U oil, but it does affect the one of Pliek U. Therefore, these active ingredients are potential for sunscreen application.