Open AccessProtective EEffect of Copaifera salikounda Heckel against Paracetamol-Induced Hepatorenal Injury in Rat
Author(s) -
Chinyere Aloke,
Nwogo Ajuka Obasi,
Chinedum Uche Emelike,
Patience Nkemjika Ogbu,
Godswill Odumero Ufebe,
Onyebuchi Federick Orinya,
Egwu Chinedu Ogbonnia,
Anthony Chinwendu Onyekwere
Publication year - 2021
Publication title -
sains malaysiana
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.251
H-Index - 29
ISSN - 0126-6039
DOI - 10.17576/jsm-2021-5004-17
Subject(s) - malondialdehyde , superoxide dismutase , pharmacology , bilirubin , glutathione peroxidase , liver injury , nephrotoxicity , oxidative stress , chemistry , lipid peroxidation , glutathione , creatinine , saline , toxicity , oral administration , medicine , biochemistry , enzyme
Drug-induced hepatorenal damage is a significant worldwide clinical challenge. In Nigeria, Copaifera salikounda seed pod ethanol extract (CSSPEE) is used in the treatment of many ailments including liver disorders. This study investigated the protective efficacy of CSSPEE against paracetamol (PCM) induced hepatorenal toxicity.Male albino Wistar rats were assigned at random into five different groups (n = 6). The normal control (Group I) was given normal saline via oral administration while Group II was given 500 mg/kg body weight of PCMvia intra-peritoneal administration; Group III was administered 100 mgkg-1 of silymarin (reference drug) while Groups IV and V were administered 200 and 400 mg kg-1 of CSSPEE, respectively, per os for seven days prior to administration of PCM. CSSPEEpretreated groups protected PCM-induced hepatorenal damage as reflected by significant diminution (P 0.05) in superoxide dismutase (SOD), glutathione peroxidase (GPx), and high-density lipoprotein (HDL) was observed in comparison to PCM group. CSSPEE also reversed liver and kidney PCMoverdose caused histopathological alterations and ameliorated the tissue histology thereby corroborating the results of biochemical findings. CSSPEE produced analogous effects comparable to those produced by silymarin (reference drug). The results indicated that oral administration of CSSPEE conferred a dose-dependent protection against paracetamol-induced oxidative damage to liver and kidney.