Open AccessC – reactive protein in saliva of non-smoking patients with periodontitis (a pilot study)
Author(s) -
Zerina Hadžić,
Ivan Puhar
Publication year - 2021
Publication title -
journal of health sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.112
H-Index - 3
eISSN - 2232-7576
pISSN - 1986-8049
DOI - 10.17532/jhsci.2021.1327
Subject(s) - saliva , medicine , periodontitis , dentistry , oral hygiene , biomarker , c reactive protein , chronic periodontitis , gastroenterology , inflammation , chemistry , biochemistry
C-reactive Protein (CRP) as an inflammatory biomarker can be easily determined in saliva, but the values of salivary CRP in periodontitis are not well-studied. The aim of this study was to analyze and determine the values of salivary CRP in non-smokers with periodontitis stage 3 or 4 before and after supragingival and subgingival full-mouth periodontal therapy.Methods: Standard periodontal parameters and saliva samples were collected in 12 non-smoking patients. Patients in the test group (n = 6) underwent supragingival and subgingival full-mouth periodontal therapy, and the control group (n = 6) received only supragingival full-mouth therapy. Both groups received the same oral hygiene instructions in addition to therapy. After 3 months, re-registration of periodontal parameters and re-sampling of saliva for analysis of salivary CRP were done for both groups.Results: Statistical analysis revealed large differences in the values of clinical periodontal parameters and CRP levels in the test group after therapy. Values of salivary CRP in the test and control groups were lower 3 months the therapy; however, the results were not statistically significant. The correlation of clinical periodontal parameters and salivary CRP varied in both groups.Conclusion: Our pilot study reveals decreased concentrations of salivary C-reactive protein in non-smoking patients following non-surgical periodontal therapy. Further studies are needed to prove the reliability of salivary CRP as a biomarker for periodontitis.